Address 2- overview of the virus
1 . The ﬁrst step- the malware binds to a receptor--> access and uncoating--> early gene expression--> duplication of viral genome--> late gene expression-> assembly of viral progeny--> exit installment payments on your Concept installment payments on your 1- Computer virus entry is a multistep method with the
ultimate goal of delivering virus-like genome (payload) into the
A. Binding to surface receptors-
- a viral receptor is cell area molecule, likely a transmembrane protein -- a malware may need multiple receptors to enter the cellular
-the capability of malware to assail certain cellular material but not other folks are typically because only the " permissive cells" display the best viral receptors. This is named virus " tropism"
-many viruses will be species-speciﬁc, somewhat due to receptor differences.
B. membrane structure and hydrophobicity
-- transmembrane proteins: a necessary protein that span across the membrane layer lipid bilayer, at least once.
-lipid bilayer- made of lipids. Arranged head to tail as they are hydrophobic.
i. What is hydrophobic?
- hydro- water
-phobic- an extremely strong feeling opposite of love- the molecules hate water. -hydrophilic- water loving head.
3. Strategy 2 . 2- the viral receptors is displayed within the cell surface.
A. Identiﬁcation of HIV pain: part you
i actually. a cell surface molecule called CD4 is the main receptor of HIV. - HIV simply infects a subset of human T cells.
- a lot of contributing factors in identiﬁcation of receptor. s.
-permissive cells-can be afflicted
-non plausible cells- may not be infected.
-macroviroc: also referred to as selzentry is definitely an inhibitor of CCR5, a coreceptor for HIV entry.
Viral tropism refers to:
The fact which the virus an affect selected cell types but not others.
W. receptor capturing and disease implications: the truth of H5N1 -H5N1: avian ﬂu malware: named after both surface glycoproteins HA ( hemagglutinin) and NA ( neuraminidase)
i. Normally affects but is not cause disease in aquatic birds. (...